Western Australian Institute for Medical Research (WAIMR)


http://www.waimr.uwa.edu.au

Dr Louise Winteringham

Louise Winteringham

Phone: +61 8 9224 0326
Email: louise.winteringham@waimr.uwa.edu.au

Dr Louise Winteringham came to Western Australia in 1990. She worked and studied in the Department of Clinical Immunology at Royal Perth Hospital completing her MSc in 1994. In 1998 she was awarded the Richard Walter Gibbon Fellowship from the Faculty of Medicine to undertake her PhD with Professor Klinken investigating the role of Myeloid Leukemia Factor 1 (Mlf1) in normal haemopoiesis and in Acute Myeloid Leukemia.

Louise is currently a senior researcher in the Laboratory for Cancer Medicine. Her research focuses on investigating pathways involved in haemopoietic cell development and lineage commitment and identifying molecules that contribute to the initiation and progression of leukaemia. Mlf1 is up regulated in a significant number of leukemias where it is associated with a poor prognosis. With her collaborators at WEHI Louise has developed mouse models of Mlf1 over expression which together with Mlf1 knock out mice will provide models for the identification and functional analysis of key molecules involved in blood cell development and leukaemia.

Qualifications

1989BSc - Cell Biology, University of Auckland, New Zealand
1994MSc - Immunology, University of Western Australia, Australia
2002PhD - Medicine and Pharmacology, University of Western Australia, Australia
Thesis Title: "Analysis of Mlf1, a novel gene involved in leukaemia"

Research Interests

  • Regulation of haemopoietic commitment and differentiation
  • Haemopoietic progenitor/stem cell biology
  • Molecules affecting the development of Leukemia

Scientific Involvement

  • Australian Society for Medical Research - Member 2001 onwards.
  • Australian Society for Biochemistry and Molecular Biology - Member 2002 onwards.
  • International Society for Stem Cell Research - Member 2006 onwards.

Major Grants Awarded

  • NHMRC (2007)
  • Ada Bartholomew Medical Research Trust (2007)
  • University of Western Australia Small Grant (2006)
  • Royal Perth Hospital Medical Research Foundation (2003, 2004, 2007)

Top 10 Publications

  1. Winteringham LN, Endersby R, Kobelke S, McCulloch RK, Williams JH, Stillitano J, Cornwall SM, Ingley E, Klinken SP. 2006. Myeloid leukemia factor 1 associates with a novel heterogeneous nuclear ribonucleoprotein U-like molecule. The Journal of Biological Chemistry 281(50):38791-800. [NCBI PubMed Entry]
  2. Winteringham LN, Kobelke S, Williams JH, Ingley E, Klinken SP. 2004. Myeloid Leukemia Factor 1 inhibits erythropoietin-induced differentiation, cell cycle exit and p27Kip1 accumulation. Oncogene 23(29):5105-9. [NCBI PubMed Entry]
  3. Lim R, Winteringham LN, Williams JH, McCulloch RK, Ingley E, Tiao JY, Lalonde JP, Tsai S, Tilbrook PA, Sun Y, Wu X, Morris SW, Klinken SP. 2002. MADM, a novel adaptor protein that mediates phosphorylation of the 14-3-3 binding site of myeloid leukemia factor 1. The Journal of Biological Chemistry 277(43):40997-1008. [NCBI PubMed Entry]
  4. Williams JH, Daly LN, Ingley E, Beaumont JG, Tilbrook PA, Lalonde JP, Stillitano JP, Klinken SP. 1999. HLS7, a hemopoietic lineage switch gene homologous to the leukemia-inducing gene MLF1. The EMBO Journal 18(20):5559-66. [NCBI PubMed Entry]